TargetMol

NoxA1ds acetate(1435893-78-9 free base)

Product Code:
 
TAR-TP1886L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1886L1-1mg1mg£177.00
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TAR-TP1886L1-5mg5mg£313.00
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TAR-TP1886L1-10mg10mg£434.00
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TAR-TP1886L1-25mg25mg£671.00
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TAR-TP1886L1-50mg50mg£914.00
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TAR-TP1886L1-100mg100mg£1,211.00
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Quantity:
TAR-TP1886L1-500mg500mg£2,344.00
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Further Information

Bioactivity:
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
CAS:
TP1886L1
Formula:
C52H92N14O17
Molecular Weight:
1185.35
Pathway:
Immunology/Inflammation
Purity:
0.9692
SMILES:
0
Target:
NADPH-oxidase

References

Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID: