TargetMol

CALP1 acetate

Product Code:
 
TAR-TP1910L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1910L1-1mg1mg£177.00
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TAR-TP1910L1-5mg5mg£313.00
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TAR-TP1910L1-10mg10mg£430.00
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TAR-TP1910L1-25mg25mg£663.00
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TAR-TP1910L1-50mg50mg£863.00
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TAR-TP1910L1-100mg100mg£1,179.00
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This product comes from: United States.
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Further Information

Bioactivity:
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 ?M) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 ?M) by inhibiting the open of calcium channel. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
CAS:
TP1910L1
Formula:
C42H79N9O12
Molecular Weight:
902.13
Pathway:
Neuroscience
Purity:
0.9963
SMILES:
CC[C@]([H])(C)[C@@]([H])(/C(O)=N/[C@@]([H])([C@@]([H])(C)O)/C(O)=N/[C@@]([H])(C(C)C)/C(O)=N/[C@@]([H])(CC(C)C)/C(O)=N/[C@@]([H])(C(C)C)/C(O)=N/[C@@]([H])(CCCCN)C(O)=O)/N=C([C@]([H])(C)/N=C([C@]([H])(C(C)C)N)O)O.CC(O)=O
Target:
CaMK

References

M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85. R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. M K Manion, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306.