TargetMol

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Product Code:
 
TAR-TP1917L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1917L1-1mg1mg£318.00
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TAR-TP1917L1-5mg5mg£629.00
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TAR-TP1917L1-10mg10mg£898.00
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TAR-TP1917L1-25mg25mg£1,299.00
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TAR-TP1917L1-50mg50mg£1,661.00
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TAR-TP1917L1-100mg100mg£2,303.00
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Further Information

Bioactivity:
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
CAS:
TP1917L1
Formula:
C49H70N12O13
Molecular Weight:
1035.15
Pathway:
GPCR/G Protein
Purity:
0.9993
SMILES:
CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@H](CC5=CC=CC=C5)C(=O)O.CC(O)=O
Target:
Bradykinin Receptor

References

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: