TargetMol

Lys-[Des-Arg9]Bradykinin acetate

Product Code:
 
TAR-TP1918L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1918L1-1mg1mg£136.00
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TAR-TP1918L1-5mg5mg£217.00
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TAR-TP1918L1-10mg10mg£291.00
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TAR-TP1918L1-25mg25mg£475.00
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TAR-TP1918L1-50mg50mg£655.00
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TAR-TP1918L1-100mg100mg£898.00
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Further Information

Bioactivity:
Lys-[Des-Arg9]Bradykinin acetate is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin.
CAS:
TP1918L1
Formula:
C52H77N13O13
Molecular Weight:
1092.27
Pathway:
GPCR/G Protein
Purity:
0.9993
SMILES:
[H]N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)CO)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCCN.CC(O)=O
Target:
Bradykinin Receptor

References

Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID: Xiao F, Jiang H, Li Z, et al.Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice.Nature Communications.2023, 14(1): 2523.