TargetMol

Spexin acetate(1370290-58-6 free base)

Product Code:
 
TAR-TP1930L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1930L1-1mg1mg£226.00
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TAR-TP1930L1-5mg5mg£430.00
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TAR-TP1930L1-10mg10mg£600.00
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TAR-TP1930L1-25mg25mg£863.00
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TAR-TP1930L1-50mg50mg£1,179.00
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TAR-TP1930L1-100mg100mg£1,589.00
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Further Information

Bioactivity:
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.
CAS:
TP1930L1
Formula:
C76H117N19O22S
Molecular Weight:
1680.94
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9543
SMILES:
CC(O)=O.O=C(O)CC[C@@H](C(N)=O)NC([C@H](C)NC(CNC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H]2N(C([C@H]([C@H](O)C)NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CC(N)=O)N)=O)=O)=O)CCC2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Target:
Neuropeptide Y Receptor

References

Reyes-Alcaraz et al (2016) Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 6 21453 PMID: Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 22 1643 PMID: Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155 1864 PMID: