TargetMol

R715 TFA(185052-09-9 free base)

Product Code:
 
TAR-TP1933
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-TP1933-1mg1mg£193.00
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Quantity:
TAR-TP1933-5mg5mg£332.00
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TAR-TP1933-10mg10mg£464.00
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TAR-TP1933-25mg25mg£699.00
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TAR-TP1933-50mg50mg£946.00
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Quantity:
TAR-TP1933-100mg100mg£1,259.00
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Quantity:
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Further Information

Bioactivity:
Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
CAS:
TP1933
Formula:
C59H82F3N13O14
Molecular Weight:
1254.36
Pathway:
GPCR/G Protein
Purity:
1
SMILES:
CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@@H]4CCCN4C(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)C.OC(C(F)(F)F)=O
Target:
Bradykinin Receptor

References

Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833 PMID: Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: