TargetMol

pep2-AVKI acetate(1315378-69-8 free base)

Product Code:
 
TAR-TP1942L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1942L1-1mg1mg£226.00
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Quantity:
TAR-TP1942L1-5mg5mg£401.00
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TAR-TP1942L1-10mg10mg£545.00
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TAR-TP1942L1-25mg25mg£815.00
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TAR-TP1942L1-50mg50mg£1,083.00
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Quantity:
TAR-TP1942L1-100mg100mg£1,420.00
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Further Information

Bioactivity:
Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
CAS:
TP1942L1
Formula:
C62H97N13O19
Molecular Weight:
1328.51
Purity:
0.9517
SMILES:
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)CCCCN)=O)C(C)C)=O)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CC(N)=O)=O)CC2=CC=C(C=C2)O.CC(O)=O

References

Hanley et al (2002) NSF ATPase and ?-/?-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron 34 53 PMID: 11931741 Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873 PMID: 11163273 Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972 PMID: 10526335 Kim et al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007