TargetMol

P110

Product Code:
 
TAR-TP1947
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TP1947-1mg1mg£99.00
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TAR-TP1947-5mg5mg£133.00
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TAR-TP1947-10mg10mg£168.00
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TAR-TP1947-25mg25mg£262.00
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Quantity:
TAR-TP1947-100mg100mg£505.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
CAS:
TP1947
Formula:
C100H179N45O25
Molecular Weight:
2411.8
Purity:
0.98
SMILES:
0

References

Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: