TargetMol

PBP10

Product Code:
 
TAR-TP1948
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1948-1mg1mg£265.00
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Further Information

Bioactivity:
Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.
CAS:
794466-43-6
Formula:
C84H126N24O15
Molecular Weight:
1712.1
Purity:
0.98
SMILES:
0

References

Forsman et al (2012) Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 189 629 PMID: Courtin et al (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 5 252 PMID: Cunningham et al (2011) Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 276 43390 PMID: