TargetMol

M40 acetate(143896-17-7 free base)

Product Code:
 
TAR-TP1992L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1992L-1mg1mg£228.00
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TAR-TP1992L-5mg5mg£462.00
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TAR-TP1992L-10mg10mg£630.00
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TAR-TP1992L-25mg25mg£946.00
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TAR-TP1992L-50mg50mg£1,267.00
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TAR-TP1992L-100mg100mg£1,661.00
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Further Information

Bioactivity:
M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
CAS:
TP1992L
Formula:
C96H149N23O26
Molecular Weight:
2041.38
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9988
SMILES:
C[C@@H](O)[C@H](NC([C@@H](NC(CN)=O)CC1=CNC2=CC=CC=C21)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N3CCC[C@H]3C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC6=CC=C(O)C=C6)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O.CC(O)=O
Target:
Neuropeptide Y Receptor

References

Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488 Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874 Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287