TargetMol

TC14012 acetate

Product Code:
 
TAR-TP2112L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-TP2112L-1mg1mg£132.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TP2112L-5mg5mg£308.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TP2112L-10mg10mg£450.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TP2112L-25mg25mg£695.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TP2112L-50mg50mg£946.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
CAS:
TP2112L
Formula:
C92H144N34O21S2
Molecular Weight:
2126.47
Pathway:
GPCR/G Protein; Autophagy; Immunology/Inflammation
Purity:
0.98
SMILES:
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=O)=O)CCCCN)=O)CCCNC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)CCCNC(N)=O)=O)=O)CC5=CC6=CC=CC=C6C=C5)=O)CCCNC(N)=N)=O)CCCNC(N)=N.CC(O)=O
Target:
CXCR

References

St?phanie Gravel, et al. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem. 2010 Dec 3;285(49):37939-43. H Tamamura, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1897-902.