TargetMol

GNE-131

Product Code:
 
TAR-TQ0014
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0014-1mg1mg£189.00
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TAR-TQ0014-5mg5mg£369.00
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TAR-TQ0014-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-TQ0014-10mg10mg£502.00
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TAR-TQ0014-25mg25mg£768.00
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TAR-TQ0014-50mg50mg£1,026.00
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Quantity:
TAR-TQ0014-100mg100mg£1,348.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
CAS:
1629063-81-5
Formula:
C23H30N4O3S
Molecular Weight:
442.58
Pathway:
Membrane transporter/Ion channel
Purity:
0.9959
SMILES:
O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
Target:
Sodium Channel

References

Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61(11):4810-4831.