TargetMol

2-Hydroxy atorvastatin calcium salt

Product Code:
 
TAR-TQ0045
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TQ0045-50mg50mgEnquire
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TAR-TQ0045-1mg1mg£168.00
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TAR-TQ0045-5mg5mg£262.00
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TAR-TQ0045-1mL1 mL * 10 mM (in DMSO)£564.00
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Further Information

Bioactivity:
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
CAS:
265989-46-6
Formula:
C66H68CaF2N4O12
Molecular Weight:
1187.34
Pathway:
Metabolism
Purity:
0.9706
SMILES:
[Ca++].CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1.CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1
Target:
Drug Metabolite

References

Borek-Dohalsk? V, et al. Validated HPLC-MS-MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma-pharmacokinetic study. Anal Bioanal Chem. 2006 Sep;386(2):275-85.