TargetMol

MI-463

Product Code:
 
TAR-TQ0058
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0058-1mg1mg£115.00
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TAR-TQ0058-5mg5mg£148.00
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TAR-TQ0058-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-TQ0058-10mg10mg£195.00
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TAR-TQ0058-25mg25mg£294.00
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TAR-TQ0058-50mg50mg£389.00
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TAR-TQ0058-100mg100mg£503.00
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This product comes from: United States.
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Further Information

Bioactivity:
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
CAS:
1628317-18-9
Formula:
C24H23F3N6S
Molecular Weight:
484.55
Pathway:
Chromatin/Epigenetic
Purity:
0.9928
SMILES:
Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2[nH]c(cc12)C#N
Target:
Epigenetic Reader Domain; Histone Methyltransferase

References

Borkin D, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27(4):589-602.