TargetMol

GNE-495

Product Code:
 
TAR-TQ0079
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0079-1mg1mg£124.00
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TAR-TQ0079-5mg5mg£148.00
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TAR-TQ0079-10mg10mg£189.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
CAS:
1449277-10-4
Formula:
C22H20FN5O2
Molecular Weight:
405.433
Pathway:
MAPK
Purity:
0.9922
SMILES:
Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1
Target:
MAPK

References

Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.