TargetMol

ND-646

Product Code:
 
TAR-TQ0243
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0243-1mg1mg£132.00
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TAR-TQ0243-5mg5mg£229.00
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TAR-TQ0243-1mL1 mL * 10 mM (in DMSO)£269.00
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TAR-TQ0243-10mg10mg£329.00
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TAR-TQ0243-25mg25mg£510.00
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TAR-TQ0243-50mg50mg£703.00
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TAR-TQ0243-100mg100mg£938.00
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Further Information

Bioactivity:
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively)
CAS:
1434639-57-2
Formula:
C28H32N4O7S
Molecular Weight:
568.65
Pathway:
Metabolism
Purity:
0.9965
SMILES:
COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1
Target:
Acetyl-CoA Carboxylase

References

Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22(10):1108-1119.