TargetMol

ARRY 520 hydrochloride

Product Code:
 
TAR-TQ0318L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0318L-1mg1mg£148.00
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TAR-TQ0318L-5mg5mg£229.00
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TAR-TQ0318L-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-TQ0318L-10mg10mg£309.00
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TAR-TQ0318L-25mg25mg£498.00
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TAR-TQ0318L-50mg50mg£688.00
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TAR-TQ0318L-100mg100mg£938.00
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This product comes from: United States.
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Further Information

Bioactivity:
ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.
CAS:
1385020-40-5
Formula:
C20H23ClF2N4O2S
Molecular Weight:
456.94
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9926
SMILES:
O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
Target:
KSP

References

Ki Hyung Kim, et al. KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. J Transl Med. 2009; 7: 63. BZ Carter, et al. Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells. Christine Lemieux, et al. ARRY-520, a Novel, Highly Selective KSP Inhibitor with Potent Anti-Proliferative Activity. AACR Annual Meeting. 2007.