TargetMol

EG00229

Product Code:
 
TAR-T11153
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11153-1mg1mg£107.00
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TAR-T11153-2mg2mg£122.00
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TAR-T11153-5mg5mg£152.00
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TAR-T11153-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T11153-10mg10mg£198.00
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TAR-T11153-25mg25mg£283.00
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TAR-T11153-50mg50mg£385.00
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TAR-T11153-100mg100mg£539.00
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This product comes from: United States.
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Further Information

Bioactivity:
EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. EG00229 is a neuropilin 1 (NRP1) receptor antagonist.
CAS:
1210945-69-9
Formula:
C19H20F3N7O7S3
Molecular Weight:
611.59
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nsnc12)C(O)=O

References

1. Jarvis A, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. 2. Grun D, et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87.