TargetMol

ERR α antagonist-1

Product Code:
 
TAR-T11230
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11230-5mg5mg£125.00
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Quantity:
TAR-T11230-1mL1 mL * 10 mM (in DMSO)£131.00
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Quantity:
TAR-T11230-10mg10mg£168.00
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Quantity:
TAR-T11230-25mg25mg£269.00
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Quantity:
TAR-T11230-50mg50mg£369.00
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Quantity:
TAR-T11230-100mg100mg£511.00
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Quantity:
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Further Information

Bioactivity:
ERRα antagonist-1 is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
CAS:
1072145-33-5
Formula:
C21H19N3S2
Molecular Weight:
377.53
Pathway:
Endocrinology/Hormones
Purity:
1
SMILES:
N1=C(SCC1)N2C(=NC3C=4C=CC=CC4C=CC=5C=CC=CC53)SCC2
Target:
Estrogen/progestogen Receptor

References

1. Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related