TargetMol

FG 7142

Product Code:
 
TAR-T11277
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11277-1mg1mg£97.00
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TAR-T11277-2mg2mg£108.00
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TAR-T11277-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T11277-5mg5mg£148.00
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TAR-T11277-10mg10mg£201.00
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TAR-T11277-25mg25mg£284.00
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TAR-T11277-50mg50mg£388.00
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TAR-T11277-100mg100mg£543.00
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TAR-T11277-500mg500mg£1,083.00
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Further Information

Bioactivity:
FG 7142 also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).
CAS:
78538-74-6
Formula:
C13H11N3O
Molecular Weight:
225.251
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.9881
SMILES:
CNC(=O)c1cc2c(cn1)[nH]c1ccccc21
Target:
GABA Receptor

References

1. Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32(5):1069-81. Epub 2006 Nov 1.