TargetMol

G-5555

Product Code:
 
TAR-T11342L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11342L-1mg1mg£109.00
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TAR-T11342L-2mg2mg£125.00
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TAR-T11342L-5mg5mg£142.00
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TAR-T11342L-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T11342L-10mg10mg£173.00
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TAR-T11342L-25mg25mg£309.00
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TAR-T11342L-50mg50mg£495.00
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TAR-T11342L-100mg100mg£688.00
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Further Information

Bioactivity:
G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
CAS:
1648863-90-4
Formula:
C25H25ClN6O3
Molecular Weight:
492.96
Pathway:
Cytoskeletal Signaling
Purity:
0.9976
SMILES:
CNc1ncc2cc(-c3ccc(cc3Cl)-c3cccc(C)n3)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1
Target:
PAK

References

1. Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. 2. Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.