TargetMol

GSK2850163

Product Code:
 
TAR-T11488
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11488-5mg5mg£122.00
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Quantity:
TAR-T11488-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T11488-10mg10mg£161.00
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TAR-T11488-25mg25mg£262.00
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TAR-T11488-50mg50mg£374.00
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Quantity:
TAR-T11488-100mg100mg£527.00
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Further Information

Bioactivity:
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
CAS:
2121989-91-9
Formula:
C24H29Cl2N3O
Molecular Weight:
446.42
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
Cc1ccc(CNC(=O)N2CCC[C@]3(CCN(Cc4ccc(Cl)c(Cl)c4)C3)C2)cc1
Target:
IRE1

References

1. Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1? Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.