TargetMol

GW806742X

Product Code:
 
TAR-T11520
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11520-5mg5mg£111.00
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Quantity:
TAR-T11520-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T11520-10mg10mg£124.00
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TAR-T11520-25mg25mg£170.00
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Quantity:
TAR-T11520-50mg50mg£230.00
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Quantity:
TAR-T11520-100mg100mg£365.00
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Further Information

Bioactivity:
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
CAS:
579515-63-2
Formula:
C25H22F3N7O4S
Molecular Weight:
573.55
Pathway:
Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
Purity:
0.9907
SMILES:
CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
Target:
MLK; VEGFR

References

1. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. 2. Yan B, et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineagekinase domain-like protein. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640.