TargetMol

KY-05009

Product Code:
 
TAR-T11793
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11793-1mg1mg£95.00
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TAR-T11793-2mg2mg£106.00
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TAR-T11793-5mg5mg£128.00
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TAR-T11793-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T11793-10mg10mg£169.00
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TAR-T11793-25mg25mg£309.00
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TAR-T11793-50mg50mg£417.00
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TAR-T11793-100mg100mg£570.00
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TAR-T11793-500mg500mg£1,099.00
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Further Information

Bioactivity:
KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity.?KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor (Ki = 100 nM).?
CAS:
1228280-29-2
Formula:
C18H16N4O2S
Molecular Weight:
352.41
Pathway:
Stem Cells; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cc1ccc(cc1)C(=O)Nc1sc(Nc2ccccc2)nc1C(N)=O
Target:
Wnt/beta-catenin

References

1. Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101.