TargetMol

MELK-IN-1

Product Code:
 
TAR-T11997
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11997-1mg1mg£111.00
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TAR-T11997-2mg2mg£130.00
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TAR-T11997-5mg5mg£168.00
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TAR-T11997-1mL1 mL * 10 mM (in DMSO)£187.00
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TAR-T11997-10mg10mg£229.00
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TAR-T11997-25mg25mg£436.00
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TAR-T11997-50mg50mg£610.00
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TAR-T11997-100mg100mg£838.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
CAS:
2095596-44-2
Formula:
C31H33N5O4
Molecular Weight:
539.636
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9914
SMILES:
COC(=O)c1ccc2NC(=O)C(=C(/Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c2c1
Target:
MELK

References

1. Edupuganti R, et al. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.