TargetMol

NS8593 hydrochloride

Product Code:
 
TAR-T12256
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12256-1mg1mg£101.00
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TAR-T12256-2mg2mg£114.00
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TAR-T12256-5mg5mg£139.00
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TAR-T12256-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T12256-10mg10mg£201.00
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TAR-T12256-25mg25mg£367.00
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TAR-T12256-50mg50mg£515.00
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TAR-T12256-100mg100mg£710.00
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Further Information

Bioactivity:
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
CAS:
875755-24-1
Formula:
C17H18ClN3
Molecular Weight:
299.8
Pathway:
Membrane transporter/Ion channel
Purity:
0.9983
SMILES:
Cl.C1C[C@@H](Nc2nc3ccccc3[nH]2)c2ccccc2C1
Target:
Potassium Channel

References

1. S?rensen US, et al. Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem. 2008 Dec 11;51(23):7625-34. 2. Str?baek D, et al. Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol. 2006 Nov;70(5):1771-82.