TargetMol

PEPA

Product Code:
 
TAR-T12406
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12406-1mg1mg£98.00
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TAR-T12406-2mg2mg£108.00
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TAR-T12406-5mg5mg£132.00
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TAR-T12406-1mL1 mL * 10 mM (in DMSO)£139.00
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TAR-T12406-10mg10mg£164.00
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TAR-T12406-25mg25mg£274.00
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TAR-T12406-50mg50mg£468.00
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TAR-T12406-100mg100mg£662.00
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Further Information

Bioactivity:
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
CAS:
141286-78-4
Formula:
C16H16F2N2O4S2
Molecular Weight:
402.43
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.98
SMILES:
NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F
Target:
iGluR

References

1. Sekiguchi M, et al. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br J Pharmacol. 1998 Apr;123(7):1294-303. 2. Ahmed AH, et al. Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry. 2010 Apr 6;49(13):2843-50. 3. Yamada D, et al. Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice. Neurosci Lett. 2011 Jan 25;488(3):242-6. 4. Zhang QG, et al. Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia. Hippocampus. 2010 Jan;20(1):65-77.