TargetMol

Alvimopan

Product Code:
 
TAR-T1242
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1242-1mg1mg£107.00
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TAR-T1242-2mg2mg£121.00
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TAR-T1242-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T1242-5mg5mg£143.00
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TAR-T1242-10mg10mg£185.00
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TAR-T1242-25mg25mg£286.00
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TAR-T1242-50mg50mg£389.00
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TAR-T1242-100mg100mg£544.00
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TAR-T1242-500mg500mg£1,099.00
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Further Information

Bioactivity:
Alvimopan is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.
CAS:
156053-89-3
Formula:
C25H32N2O4
Molecular Weight:
424.541
Pathway:
Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Purity:
0.9997
SMILES:
C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(O)=O)CC[C@@]1(C)c1cccc(O)c1
Target:
Opioid Receptor

References

1. Cassel JA, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):29-36.