TargetMol

SHA 68

Product Code:
 
TAR-T12895
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
CAS:
847553-89-3
Formula:
C26H24FN3O3
Molecular Weight:
445.494
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
Fc1ccc(CNC(=O)N2CCN3C(C2)C(OC3=O)(c2ccccc2)c2ccccc2)cc1
Target:
Neuropeptide Y Receptor

References

1. Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901. 2. Ensho T, et al. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.Neuropeptides. 2017 Oct;65:21-27.