TargetMol

T16Ainh-A01

Product Code:
 
TAR-T13059
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13059-5mg5mg£124.00
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Quantity:
TAR-T13059-10mg10mg£157.00
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TAR-T13059-25mg25mg£243.00
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TAR-T13059-50mg50mg£389.00
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TAR-T13059-100mg100mg£544.00
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Quantity:
TAR-T13059-200mg200mg£748.00
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This product comes from: United States.
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Further Information

Bioactivity:
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).
CAS:
552309-42-9
Formula:
C19H20N4O3S2
Molecular Weight:
416.51
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc1O
Target:
Chloride channel

References

1. Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov;469(11):1443-1455. 2. Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74.