TargetMol

Trovafloxacin

Product Code:
 
TAR-T13231
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-T13231-100mg100mgEnquire
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TAR-T13231-50mg50mgEnquire
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TAR-T13231-1mL1 mL * 10 mM (in DMSO)£173.00
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This product comes from: United States.
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Further Information

Bioactivity:
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
CAS:
147059-72-1
Formula:
C20H15F3N4O3
Molecular Weight:
416.36
Pathway:
DNA Damage/DNA Repair; Microbiology/Virology
Purity:
0.9927
SMILES:
[H][C@@]12CN(C[C@]1([H])[C@H]2N)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F
Target:
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic

References

1. Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. 2. Poon IK, et al. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 2014 Mar 20;507(7492):329-34. 3. Gootz TD, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.