TargetMol

AZD5423

Product Code:
 
TAR-T14377
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14377-1mg1mg£103.00
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TAR-T14377-2mg2mg£118.00
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TAR-T14377-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T14377-5mg5mg£148.00
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TAR-T14377-10mg10mg£201.00
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TAR-T14377-25mg25mg£309.00
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TAR-T14377-50mg50mg£495.00
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TAR-T14377-100mg100mg£688.00
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This product comes from: United States.
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Further Information

Bioactivity:
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
CAS:
1034148-04-3
Formula:
C25H21F4N3O3
Molecular Weight:
487.455
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
COc1cccc(c1)[C@@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)[C@H](C)NC(=O)C(F)(F)F
Target:
Glucocorticoid Receptor

References

1. Werkstr?m V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. 2. Gauvreau GM, et al. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.