TargetMol

CBR-5884

Product Code:
 
TAR-T14884
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14884-2mg2mg£102.00
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TAR-T14884-5mg5mg£121.00
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TAR-T14884-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T14884-10mg10mg£148.00
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TAR-T14884-25mg25mg£254.00
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TAR-T14884-50mg50mg£388.00
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Quantity:
TAR-T14884-100mg100mg£544.00
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Further Information

Bioactivity:
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
CAS:
681159-27-3
Formula:
C14H12N2O4S2
Molecular Weight:
336.38
Pathway:
Metabolism;
Purity:
1
SMILES:
CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
Target:
Dehydrogenase

References

1. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.