TargetMol

CMS-121

Product Code:
 
TAR-T14991
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14991-2mg2mg£100.00
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TAR-T14991-5mg5mg£119.00
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TAR-T14991-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T14991-10mg10mg£147.00
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TAR-T14991-25mg25mg£213.00
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TAR-T14991-50mg50mg£284.00
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TAR-T14991-100mg100mg£389.00
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Further Information

Bioactivity:
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.
CAS:
1353224-53-9
Formula:
C20H19NO3
Molecular Weight:
321.376
Pathway:
Metabolism
Purity:
0.9948
SMILES:
Oc1ccc(cc1O)-c1cc(OC2CCCC2)c2ccccc2n1
Target:
Acetyl-CoA Carboxylase

References

1. Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. 2. Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. 3. Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13.