TargetMol

Ebrotidine

Product Code:
 
TAR-T15195
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15195-2mg2mg£100.00
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TAR-T15195-5mg5mg£118.00
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TAR-T15195-1mL1 mL * 10 mM (in DMSO)£123.00
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TAR-T15195-10mg10mg£148.00
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Further Information

Bioactivity:
Ebrotidine is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.
CAS:
100981-43-9
Formula:
C14H17BrN6O2S3
Molecular Weight:
477.41
Pathway:
GPCR/G Protein; Neuroscience; Immunology/Inflammation
Purity:
0.98
SMILES:
NC(=N)Nc1nc(CSCCNC=NS(=O)(=O)c2ccc(Br)cc2)cs1
Target:
Histamine Receptor

References

1. Agut J, S?nchez JC, Sacrist?n A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9. 2. Palop D, Agut J, M?rquez M, Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46. 3. Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67. 4. Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.