TargetMol

Gardiquimod

Product Code:
 
TAR-T15371
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T15371-50mg50mgEnquire
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TAR-T15371-1mg1mg£95.00
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TAR-T15371-2mg2mg£105.00
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TAR-T15371-5mg5mg£125.00
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TAR-T15371-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T15371-10mg10mg£161.00
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TAR-T15371-25mg25mg£222.00
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Further Information

Bioactivity:
Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10?μM, Gardiquimod specifically activates TLR7.
CAS:
1020412-43-4
Formula:
C17H23N5O
Molecular Weight:
313.405
Pathway:
Immunology/Inflammation; Proteases/Proteasome; Microbiology/Virology
Purity:
0.9802
SMILES:
CCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
Target:
TLR; HIV Protease

References

1. Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18. 2. Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306.