TargetMol

GNF351

Product Code:
 
TAR-T15410
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15410-1mg1mg£100.00
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TAR-T15410-5mg5mg£140.00
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TAR-T15410-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T15410-10mg10mg£189.00
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TAR-T15410-25mg25mg£309.00
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TAR-T15410-50mg50mg£510.00
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TAR-T15410-100mg100mg£662.00
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TAR-T15410-200mg200mg£870.00
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Further Information

Bioactivity:
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).
CAS:
1227634-69-6
Formula:
C24H25N7
Molecular Weight:
411.513
Pathway:
Immunology/Inflammation
Purity:
0.9904
SMILES:
CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
Target:
Aryl Hydrocarbon Receptor

References

1. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.