TargetMol

Hypothemycin

Product Code:
 
TAR-T15542
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15542-5mg5mg£1,002.00
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TAR-T15542-50mg50mg£3,717.00
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TAR-T15542-100mg100mg£5,605.00
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This product comes from: United States.
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Further Information

Bioactivity:
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).
CAS:
76958-67-3
Formula:
C19H22O8
Molecular Weight:
378.377
Purity:
0.98
SMILES:
[H][C@@]12C[C@H](O)[C@H](O)C(=O)C=C/C[C@H](C)OC(=O)c3c(O)cc(OC)cc3[C@H]1O2

References

1. Schirmer A, et al. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4234-9. 2. Nishino M, et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei. Elife. 2013 Jul 9;2:e00712.