TargetMol

Indibulin

Product Code:
 
TAR-T15576
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15576-2mg2mg£98.00
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TAR-T15576-5mg5mg£115.00
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TAR-T15576-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T15576-10mg10mg£143.00
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TAR-T15576-25mg25mg£226.00
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TAR-T15576-50mg50mg£322.00
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TAR-T15576-100mg100mg£466.00
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Further Information

Bioactivity:
Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.
CAS:
204205-90-3
Formula:
C22H16ClN3O2
Molecular Weight:
389.84
Pathway:
Apoptosis; Cytoskeletal Signaling
Purity:
0.9983
SMILES:
Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1
Target:
Apoptosis; Microtubule Associated

References

1. Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363.