TargetMol

Linopirdine

Product Code:
 
TAR-T15758
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15758-1mg1mg£99.00
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TAR-T15758-2mg2mg£111.00
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TAR-T15758-5mg5mg£135.00
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TAR-T15758-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T15758-10mg10mg£173.00
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TAR-T15758-25mg25mg£262.00
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TAR-T15758-50mg50mg£402.00
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TAR-T15758-100mg100mg£544.00
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TAR-T15758-200mg200mg£756.00
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TAR-T15758-500mg500mg£1,091.00
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Further Information

Bioactivity:
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating release of acetylcholine and other neurotransmitters.Linopirdine is a putative cognition-enhancing drug that increases acetylcholine release in rat brain tissue.
CAS:
105431-72-9
Formula:
C26H21N3O
Molecular Weight:
391.474
Pathway:
Membrane transporter/Ion channel
Purity:
0.9992
SMILES:
O=C1N(c2ccccc2C1(Cc1ccncc1)Cc1ccncc1)c1ccccc1
Target:
Potassium Channel; TRP/TRPV Channel

References

1. Schnee ME, et al. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Nassoiy SP, et al. Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements afterhemorrhagic shock in rats. J Biomed Sci. 2017 Jan 17;24(1):8. 3. Neacsu C, et al. The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci. 2010;114(3):332-40.