TargetMol

Loxoribine

Product Code:
 
TAR-T15777
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15777-1mg1mg£106.00
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TAR-T15777-2mg2mg£121.00
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TAR-T15777-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T15777-5mg5mg£148.00
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TAR-T15777-10mg10mg£209.00
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TAR-T15777-25mg25mg£302.00
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TAR-T15777-50mg50mg£418.00
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TAR-T15777-100mg100mg£575.00
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Further Information

Bioactivity:
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
CAS:
121288-39-9
Formula:
C13H17N5O6
Molecular Weight:
339.308
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.9973
SMILES:
Nc1nc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(=O)n(CC=C)c2c(=O)[nH]1
Target:
Influenza Virus; TLR

References

1. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. 2. Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33. 3. Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.