TargetMol

ML349

Product Code:
 
TAR-T16108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16108-1mg1mg£97.00
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TAR-T16108-2mg2mg£107.00
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TAR-T16108-5mg5mg£132.00
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TAR-T16108-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T16108-10mg10mg£173.00
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TAR-T16108-25mg25mg£294.00
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TAR-T16108-50mg50mg£436.00
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TAR-T16108-100mg100mg£610.00
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TAR-T16108-500mg500mg£1,219.00
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Further Information

Bioactivity:
ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).
CAS:
890819-86-0
Formula:
C23H22N2O4S2
Molecular Weight:
454.56
Pathway:
Metabolism;
Purity:
0.9959
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1
Target:
Phospholipase

References

1. Won SJ, et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Dec 16;11(12):3374-3382. 2. Adibekian A, et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). 3. Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.