TargetMol

NCT-502

Product Code:
 
TAR-T16277
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16277-2mg2mg£97.00
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TAR-T16277-5mg5mg£112.00
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TAR-T16277-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T16277-10mg10mg£134.00
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TAR-T16277-25mg25mg£201.00
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TAR-T16277-50mg50mg£274.00
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TAR-T16277-100mg100mg£422.00
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TAR-T16277-500mg500mg£859.00
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This product comes from: United States.
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Further Information

Bioactivity:
NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.
CAS:
1542213-00-2
Formula:
C18H20F3N5S
Molecular Weight:
395.45
Pathway:
Metabolism
Purity:
0.995
SMILES:
Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
Target:
Dehydrogenase

References

1. Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1727-1739.