TargetMol

UCL 2077

Product Code:
 
TAR-T17197
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17197-1mg1mg£136.00
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TAR-T17197-2mg2mg£164.00
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TAR-T17197-5mg5mg£205.00
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TAR-T17197-1mL1 mL * 10 mM (in DMSO)£219.00
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TAR-T17197-10mg10mg£262.00
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TAR-T17197-25mg25mg£417.00
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TAR-T17197-50mg50mg£584.00
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TAR-T17197-100mg100mg£785.00
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TAR-T17197-500mg500mg£1,540.00
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Further Information

Bioactivity:
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker?with IC50 of 500 nM in hippocampal neurons in culture, having minimal effects on Ca2+ channels, action potentials, input resistance, and the medium afterhyperpolarization.
CAS:
918311-87-2
Formula:
C25H22N2
Molecular Weight:
350.465
Purity:
0.9938
SMILES:
C(NC(c1ccccc1)(c1ccccc1)c1ccccc1)c1cccnc1

References

1. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502. 2. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.