TargetMol

UNC0321

Product Code:
 
TAR-T17204
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17204-1mg1mg£102.00
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TAR-T17204-2mg2mg£116.00
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TAR-T17204-5mg5mg£146.00
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TAR-T17204-10mg10mg£189.00
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TAR-T17204-25mg25mg£341.00
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TAR-T17204-50mg50mg£499.00
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TAR-T17204-100mg100mg£688.00
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Further Information

Bioactivity:
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
CAS:
1238673-32-9
Formula:
C27H45N7O3
Molecular Weight:
515.703
Pathway:
Chromatin/Epigenetic
Purity:
0.9937
SMILES:
COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
Target:
Histone Methyltransferase

References

1. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57. 2. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.