TargetMol

ATP-polyamine-biotin

Product Code:
 
TAR-T17454
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17454-2mg2mg£711.00
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TAR-T17454-5mg5mg£1,187.00
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Further Information

Bioactivity:
ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ? 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.
CAS:
1800401-93-7
Formula:
C32H58N11O14P3S
Molecular Weight:
945.86
Purity:
0.98
SMILES:
[H][C@]12CS[C@@H](CCCCC(=O)NCCCN(C)CCCCN(C)CCCNP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)[C@@]1([H])NC(=O)N2

References

1. Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.