TargetMol

RGFP966

Product Code:
 
TAR-T1762
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1762-1mg1mg£95.00
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TAR-T1762-2mg2mg£106.00
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TAR-T1762-5mg5mg£128.00
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TAR-T1762-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T1762-10mg10mg£161.00
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TAR-T1762-25mg25mg£230.00
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TAR-T1762-50mg50mg£322.00
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TAR-T1762-100mg100mg£483.00
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This product comes from: United States.
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Further Information

Bioactivity:
RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 μM.
CAS:
1357389-11-7
Formula:
C21H19FN4O
Molecular Weight:
362.4
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9977
SMILES:
Nc1cc(F)ccc1NC(=O)C=Cc1cnn(CC=Cc2ccccc2)c1
Target:
HDAC

References

1. Malvaez M, et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52. 2. Leus NG, et al. HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-?B p65 transcriptional activity. Biochem Pharmacol. 2016 May 15;108:58-74. 3. Wells CE, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One. 2013 Jul 22;8(7):e68915. 4. Jia H, et al. The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. PLoS One. 2016 Mar 31;11(3):e0152498.