TargetMol

HDAC-IN-7

Product Code:
 
TAR-T2025
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2025-1mg1mg£115.00
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TAR-T2025-2mg2mg£134.00
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TAR-T2025-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-T2025-5mg5mg£182.00
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TAR-T2025-10mg10mg£262.00
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TAR-T2025-25mg25mg£454.00
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TAR-T2025-50mg50mg£631.00
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TAR-T2025-100mg100mg£868.00
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This product comes from: United States.
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Further Information

Bioactivity:
HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10).
CAS:
743420-02-2
Formula:
C22H19FN4O2
Molecular Weight:
390.418
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9786
SMILES:
Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)C=Cc2cccnc2)cc1
Target:
HDAC

References

1. Ning ZQ, et al. Chidamide (CS055/HBI-82000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9. 2. Gong K, et al. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells. Biochem J. 2012 May 1;443(3):735-46. 3. Zhao B, et al. Chidamide, a histone deacetylase inhibitor, functions as a tumor inhibitor by modulating the ratio of Bax/Bcl-2 and P21 in pancreatic cancer. Oncol Rep. 2015 Jan;33(1):304-10. 4. Chang Y Y, Wu H L, Fang H, et al. Comparison of three chemometric methods for processing HPLC-DAD data with time shifts: Simultaneous determination of ten molecular targeted anti-tumor drugs in different biological samples[J]. Talanta. 2021, 224: 121798.