TargetMol

GS967

Product Code:
 
TAR-T2049
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2049-2mg2mg£95.00
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TAR-T2049-5mg5mg£109.00
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TAR-T2049-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T2049-10mg10mg£128.00
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TAR-T2049-25mg25mg£201.00
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TAR-T2049-50mg50mg£310.00
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TAR-T2049-100mg100mg£490.00
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TAR-T2049-200mg200mg£678.00
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TAR-T2049-500mg500mg£1,010.00
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Further Information

Bioactivity:
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
CAS:
1262618-39-2
Formula:
C14H7F6N3O
Molecular Weight:
347.22
Pathway:
Membrane transporter/Ion channel
Purity:
0.9962
SMILES:
FC(F)(F)Oc1ccc(cc1)-c1ccc2nnc(n2c1)C(F)(F)F
Target:
Sodium Channel

References

1. Belardinelli L, et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. J Pharmacol Exp Ther. 2013 Jan;344(1):23-32. 2. Potet F, et al. Use-Dependent Block of Human Cardiac Sodium Channels by GS967. Mol Pharmacol. 2016 Jul;90(1):52-60. 3. Bonatti R, et al. Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. Heart Rhythm. 2014 Oct;11(10):1827-35.