TargetMol

NE-100 hydrochloride?

Product Code:
 
TAR-T20797
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20797-1mg1mg£101.00
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TAR-T20797-2mg2mg£112.00
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TAR-T20797-5mg5mg£138.00
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TAR-T20797-10mg10mg£182.00
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TAR-T20797-25mg25mg£258.00
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TAR-T20797-50mg50mg£349.00
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TAR-T20797-100mg100mg£485.00
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TAR-T20797-200mg200mg£662.00
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Quantity:
TAR-T20797-500mg500mg£946.00
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Further Information

Bioactivity:
NE100 HCl is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
CAS:
149409-57-4
Formula:
C23H34ClNO2
Molecular Weight:
391.98
Pathway:
GPCR/G Protein
Purity:
0.9885
SMILES:
Cl.CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
Target:
Sigma receptor

References

1. Lenart L, et al. The role of sigma-1 receptor and brain-derived neurotrophic factor in the development of diabetes and comorbid depression in streptozotocin-induced diabetic rats. Psychopharmacology (Berl). 2016 Apr;233(7):1269-78. 2. Di T, et al. Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice. Front Mol Neurosci. 2017 Sep 6;10:287. 3. Chen T, et al. Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT-1 via ?(1) receptor-mediated PKC activation in the hippocampal dentate gyrus of rats. Glia. 2017 Sep;65(9):1491-1503. 4. Li D, et al. Sigma-1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage-gated calcium ions channels. CNS Neurosci Ther. 2017 Dec;23(12):930-939.